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KMID : 1190620090050010005
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Journal of the Korean Wound Care Society
2009 Volume.5 No. 1 p.5 ~ p.10
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Effect of Rice Cell Origin Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor (rrhGM-CSF) on Wound Healing in Hamster Skin
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Han Kyu-Boem
Cheon Yong-Kang
Heo Si-Hyun
Kim Wan-Jong
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Abstract
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GM-CSF is a multipotent growth factor, which also plays an important role during the process of wound healing. rrhGM-CSF was specifically produced from rice cell culture in our laboratory. The rrhGM-CSF contains more oligosaccharide side chains than any other types of GM-CSF. This work was taken to evaluate the influence on wound-healing of rrhGM-CSF in male golden hamsters. Full thickness skin defects of 9 mm in diameter were made in the back of hamsters, and 100 ?l ointment containing rrhGM-CSF 23.9 ?g/ml was applied. Control groups were given ointment without rrhGM-CSF. The wound sizes were relatively reduced and skin was well regenerated in the experimental group compared with the control group. And also, histologically, reepithelialization and architecture of the skin following injury were prominent in the experimental group. Since this type of GM-CSF has highly glycosylated side chains, the effectiveness might be retain longer and stable, regarding acceleration of wound healing in the animal model. The present study has important implications for further development of the therapeutic manipulation of wound healing using rrhGM-CSF. (J Korean Wound Management Soc 2009;5:5-10)
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KEYWORD
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rrhGM-CSF, Wound healing, Hamster
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